New 2025 Study Data

Zepbound vs. Wegovy:
The 2025 Showdown

The battle of the weight loss injectables is heating up. We break down the latest head-to-head results, dosing complexities, and which one actually works faster.

For years, Wegovy (Semaglutide) was the undisputed king of weight loss. But in 2025, a challenger has taken the crown.

A major head-to-head study published in late 2024 has confirmed that Zepbound (Tirzepatide) leads to significantly greater weight loss than Wegovy. However, weight loss isn't the only factor—heart health, side effects, and dosing schedules play a huge role in which drug your doctor might prescribe.

The "Dual Action" Difference

Why is Zepbound stronger? It hits two targets instead of one.

  • Wegovy (Semaglutide) Mimics GLP-1 only. This hormone signals fullness to your brain and slows down digestion.
  • Zepbound (Tirzepatide) Mimics GLP-1 AND GIP. This "dual agonist" approach not only signals fullness but also helps improve how your body breaks down sugar and fat.

Head-to-Head: The Stats

Feature Wegovy Zepbound
Avg. Weight Loss ~15% (at 68 weeks) ~20-21% (at 72 weeks)
Cardiovascular Benefit FDA Approved (Heart Health) Studies Ongoing
Monthly Cost (Est.) $1,350+ $1,060+ (Savings card avail.)
Dosing Steps 5 Steps (0.25mg → 2.4mg) 6 Steps (2.5mg → 15mg)
Don't Get Lost

Struggling with the "Titration Schedule"?

Moving from 2.5mg to 5mg? Or 0.5mg to 1.0mg? These meds require precise weekly increases. DoseMed tracks your exact dosage history so you can show your doctor exactly what you took and when.

Start Tracking Doses
Current Dose Week 5

Zepbound

5mg • Injection • Tuesday

The "Gastric Emptying" Risk

Both drugs work by slowing down your stomach. This is great for feeling full, but it introduces a hidden risk: Delayed Absorption of Other Meds.

If you take daily oral medications (like birth control, antibiotics, or antidepressants), they might sit in your stomach longer than intended, potentially changing how effective they are.

Interaction Warning

Before starting Zepbound or Wegovy, enter all your current pills into the DoseMed App. Our AI Interaction Checker will instantly flag potential absorption issues.

Common 2025 Side Effects

New data confirms that nausea remains the #1 complaint for both, but Zepbound users report slightly less nausea in some trials compared to Wegovy users at equivalent doses.

  • Nausea & Vomiting Most common during the first 2 days after injection.
  • Fatigue Your body is running on a calorie deficit. Energy dips are normal.

The Verdict?

If your primary goal is maximum weight loss, Zepbound is the statistical winner in 2025. If you have heart disease history, Wegovy is currently the safer, FDA-approved choice for heart protection.

Always consult your doctor before switching medications.